Astrocytes play a crucial role in the formation and evolution of MS lesions–Yes
D Pitt, G Ponath - Multiple Sclerosis Journal, 2019 - journals.sagepub.com
D Pitt, G Ponath
Multiple Sclerosis Journal, 2019•journals.sagepub.comMultiple Sclerosis Journal 25 (1) 16 journals. sagepub. com/home/msj target tissue cells.
Hepatic stellate cells, which share many similarities with astrocytes, including the expression
of glial fibrillary acidic protein (GFAP), acquire a highly reactive and proliferative phenotype
in autoimmune hepatitis and are major contributors to hepatic fibrosis. 7 Thus, participation
in the autoimmune process is not unique to astrocytes, but a general feature of target tissue
cells with innate immune capabilities. Consequently, the predisposition of the target tissue to …
Hepatic stellate cells, which share many similarities with astrocytes, including the expression
of glial fibrillary acidic protein (GFAP), acquire a highly reactive and proliferative phenotype
in autoimmune hepatitis and are major contributors to hepatic fibrosis. 7 Thus, participation
in the autoimmune process is not unique to astrocytes, but a general feature of target tissue
cells with innate immune capabilities. Consequently, the predisposition of the target tissue to …
Multiple Sclerosis Journal 25 (1)
16 journals. sagepub. com/home/msj target tissue cells. Hepatic stellate cells, which share many similarities with astrocytes, including the expression of glial fibrillary acidic protein (GFAP), acquire a highly reactive and proliferative phenotype in autoimmune hepatitis and are major contributors to hepatic fibrosis. 7 Thus, participation in the autoimmune process is not unique to astrocytes, but a general feature of target tissue cells with innate immune capabilities. Consequently, the predisposition of the target tissue to promote local inflammation may in part determine an individual’s susceptibility to organspecific autoimmunity.
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