[HTML][HTML] Inactivation of adenosine A2A receptor attenuates basal and angiotensin II-induced ROS production by Nox2 in endothelial cells
S Thakur, J Du, S Hourani, C Ledent, JM Li - Journal of biological chemistry, 2010 - ASBMB
Endothelial cells (ECs) express a Nox2 enzyme, which, by generating reactive oxygen
species (ROS), contributes to EC redox signaling and angiotensin II (AngII)-induced
endothelial dysfunction. ECs also express abundantly an adenosine A 2A receptor (A 2A R),
but its role in EC ROS production remains unknown. In this study, we investigated the role of
A 2A R in the regulation of Nox2 activity and signaling in ECs with or without acute AngII
stimulation. In cultured ECs (SVEC4–10), AngII (100 nm, 30 min) significantly increased …
species (ROS), contributes to EC redox signaling and angiotensin II (AngII)-induced
endothelial dysfunction. ECs also express abundantly an adenosine A 2A receptor (A 2A R),
but its role in EC ROS production remains unknown. In this study, we investigated the role of
A 2A R in the regulation of Nox2 activity and signaling in ECs with or without acute AngII
stimulation. In cultured ECs (SVEC4–10), AngII (100 nm, 30 min) significantly increased …