Proteinase 3-ANCA vasculitis versus myeloperoxidase-ANCA vasculitis
M Hilhorst, P van Paassen… - Journal of the American …, 2015 - journals.lww.com
In patients with GN or vasculitis, ANCAs are directed against proteinase 3 (PR3) or
myeloperoxidase (MPO). The differences between PR3-ANCA-associated vasculitis (AAV)
and MPO-AAV described in the past have been supplemented during the last decade. In this
review, we discuss the differences between these two small-vessel vasculitides, focusing
especially on possible etiologic and pathophysiologic differences. PR3-AAV is more
common in northern parts of the world, whereas MPO-AAV is more common in southern …
myeloperoxidase (MPO). The differences between PR3-ANCA-associated vasculitis (AAV)
and MPO-AAV described in the past have been supplemented during the last decade. In this
review, we discuss the differences between these two small-vessel vasculitides, focusing
especially on possible etiologic and pathophysiologic differences. PR3-AAV is more
common in northern parts of the world, whereas MPO-AAV is more common in southern …