Neutrophil serine proteases promote IL-1β generation and injury in necrotizing crescentic glomerulonephritis
A Schreiber, CTN Pham, Y Hu… - Journal of the …, 2012 - journals.lww.com
The pathogenesis of anti–neutrophil cytoplasmic antibody (ANCA)–associated necrotizing
crescentic GN (NCGN) is incompletely understood. Dipeptidyl peptidase I (DPPI) is a
cysteine protease required for the activation of neutrophil serine proteases (NSPs) cathepsin
G, neutrophil elastase, and proteinase 3, which are enzymes that modulate inflammation.
We used a mouse model of anti–myeloperoxidase (MPO) antibody–induced NCGN to
determine whether active NSPs contribute to its pathogenesis. MPO-deficient animals …
crescentic GN (NCGN) is incompletely understood. Dipeptidyl peptidase I (DPPI) is a
cysteine protease required for the activation of neutrophil serine proteases (NSPs) cathepsin
G, neutrophil elastase, and proteinase 3, which are enzymes that modulate inflammation.
We used a mouse model of anti–myeloperoxidase (MPO) antibody–induced NCGN to
determine whether active NSPs contribute to its pathogenesis. MPO-deficient animals …