Major histocompatibility complex HLA region largely explains the genetic variance exercised on neutrophil membrane proteinase 3 expression
S von Vietinghoff, A Busjahn… - Journal of the …, 2006 - journals.lww.com
ANCA-associated vasculitides, a common cause of rapidly progressive glomerulonephritis,
are influenced by genetic variance. Neutrophil membrane expression of the ANCA antigen
proteinase 3 (PR3) is pathogenically important. A subset of membrane PR3–positive
neutrophils can be distinguished from a membrane-negative subset in any given subject.
The percentage of membrane PR3–positive neutrophils is genetically determined. In this
study, 17 pairs of HLA-matched siblings were typed for their percentage of membrane PR3 …
are influenced by genetic variance. Neutrophil membrane expression of the ANCA antigen
proteinase 3 (PR3) is pathogenically important. A subset of membrane PR3–positive
neutrophils can be distinguished from a membrane-negative subset in any given subject.
The percentage of membrane PR3–positive neutrophils is genetically determined. In this
study, 17 pairs of HLA-matched siblings were typed for their percentage of membrane PR3 …