Membrane expression of proteinase 3 is genetically determined
A Schreiber, A Busjahn, FC Luft… - Journal of the American …, 2003 - journals.lww.com
Isolated human neutrophils exhibit a bimodal membrane proteinase 3 (PR3) expression.
PR3 is the main target antigen in Wegener granulomatosis (WG). Cells with low expression
can be easily distinguished from cell subsets with high expression. In a recent study, a large
neutrophil subset expressing membrane PR3 (mPR3+) was a risk factor for systemic ANCA-
associated vasculitis. PR3 membrane expression patterns are quite stable in a given
individual, raising the possibility of genetic variance. The aims of this study were:(1) to …
PR3 is the main target antigen in Wegener granulomatosis (WG). Cells with low expression
can be easily distinguished from cell subsets with high expression. In a recent study, a large
neutrophil subset expressing membrane PR3 (mPR3+) was a risk factor for systemic ANCA-
associated vasculitis. PR3 membrane expression patterns are quite stable in a given
individual, raising the possibility of genetic variance. The aims of this study were:(1) to …