[HTML][HTML] Cyclin-dependent kinase 5 (Cdk5)-dependent phosphorylation of p70 ribosomal S6 kinase 1 (S6K) is required for dendritic spine morphogenesis
The maturation and maintenance of dendritic spines depends on neuronal activity and
protein synthesis. One potential mechanism involves mammalian target of rapamycin, which
promotes protein synthesis through phosphorylation of eIF4E-binding protein and p70
ribosomal S6 kinase 1 (S6K). Upon extracellular stimulation, mammalian target of rapamycin
phosphorylates S6K at Thr-389. S6K also undergoes phosphorylation at other sites,
including four serine residues in the autoinhibitory domain. Despite extensive biochemical …
protein synthesis. One potential mechanism involves mammalian target of rapamycin, which
promotes protein synthesis through phosphorylation of eIF4E-binding protein and p70
ribosomal S6 kinase 1 (S6K). Upon extracellular stimulation, mammalian target of rapamycin
phosphorylates S6K at Thr-389. S6K also undergoes phosphorylation at other sites,
including four serine residues in the autoinhibitory domain. Despite extensive biochemical …