[HTML][HTML] p35 is required for CDK5 activation in cellular senescence
D Mao, PW Hinds - Journal of biological chemistry, 2010 - ASBMB
The retinoblastoma tumor suppressor gene (RB-1) is a key regulator of cellular senescence.
Expression of the retinoblastoma protein (pRB) in human tumor cells that lack it results in
senescence-like changes. The induction of the senescent phenotype by pRB requires the
postmitotic kinase CDK5, the best known function of which is in neuronal development and
postmitotic neuronal activities. Activation of CDK5 in neurons depends on its activators p35
and p39; however, little is known about how CDK5 is activated in non-neuronal senescent …
Expression of the retinoblastoma protein (pRB) in human tumor cells that lack it results in
senescence-like changes. The induction of the senescent phenotype by pRB requires the
postmitotic kinase CDK5, the best known function of which is in neuronal development and
postmitotic neuronal activities. Activation of CDK5 in neurons depends on its activators p35
and p39; however, little is known about how CDK5 is activated in non-neuronal senescent …