Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling.
K Ley, TF Tedder - Journal of immunology (Baltimore, Md.: 1950), 1995 - journals.aai.org
K Ley, TF Tedder
Journal of immunology (Baltimore, Md.: 1950), 1995•journals.aai.orgAmong the earliest signs of inflammation is the capture of leukocytes from the blood stream
and their subsequent rolling along the endothelium of postcapillary venules. This
commentary summarizes recent insight into the molecular basis of leukocyte rolling gained
from gene-targeted mice, Ab blocking studies, and in vitro and in vivo reconstitution assays.
These data reveal how the selectins individually and collectively contribute to the process of
leukocyte capture and subsequent rolling on vascular endothelium.
and their subsequent rolling along the endothelium of postcapillary venules. This
commentary summarizes recent insight into the molecular basis of leukocyte rolling gained
from gene-targeted mice, Ab blocking studies, and in vitro and in vivo reconstitution assays.
These data reveal how the selectins individually and collectively contribute to the process of
leukocyte capture and subsequent rolling on vascular endothelium.
Abstract
Among the earliest signs of inflammation is the capture of leukocytes from the blood stream and their subsequent rolling along the endothelium of postcapillary venules. This commentary summarizes recent insight into the molecular basis of leukocyte rolling gained from gene-targeted mice, Ab blocking studies, and in vitro and in vivo reconstitution assays. These data reveal how the selectins individually and collectively contribute to the process of leukocyte capture and subsequent rolling on vascular endothelium.
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