Late renal allograft loss is mainly the result of progressive histological damage. Both
underimmunosuppression (rejection phenomena) and overimmunosuppression (calcineurin
inhibitor nephrotoxicity) contribute to the progression of chronic histological damage. The
current study was performed to elucidate the complementary impact of immune and
nonimmune phenomena on renal allograft histology and function. By performing protocol
biopsies, it was demonstrated that clinical and subclinical acute cellular rejection …