[HTML][HTML] Direct Measurement of Nitric Oxide Generation in the Ischemic Heart Using Electron Paramagnetic Resonance Spectroscopy (∗)
JL Zweier, P Wang, P Kuppusamy - Journal of Biological Chemistry, 1995 - ASBMB
Nitric oxide, NO, exerts numerous important regulatory functions in biological tissues and
has been hypothesized to have a role in the pathogenesis of cellular injury in a number of
diseases. It has been suggested that alterations in NO generation are a critical cause of
injury in the ischemic heart. However, the precise alterations in NO generation which occur
are not known, and there is considerable controversy regarding whether myocardial
ischemia results in increased or decreased NO formation. Therefore, electron paramagnetic …
has been hypothesized to have a role in the pathogenesis of cellular injury in a number of
diseases. It has been suggested that alterations in NO generation are a critical cause of
injury in the ischemic heart. However, the precise alterations in NO generation which occur
are not known, and there is considerable controversy regarding whether myocardial
ischemia results in increased or decreased NO formation. Therefore, electron paramagnetic …