Thioredoxin1 as a negative regulator of cardiac hypertrophy
T Ago, J Sadoshima - Antioxidants & redox signaling, 2007 - liebertpub.com
T Ago, J Sadoshima
Antioxidants & redox signaling, 2007•liebertpub.comExcessive reactive oxygen species (ROS) play an important role in the development of
cardiac hypertrophy. In contrast, antioxidants scavenge ROS, thereby maintaining the
reduced environment of cells and inhibiting hypertrophy in the heart. Thioredoxin1 (Trx1) not
only functions as a major antioxidant in the heart but also interacts with important signaling
molecules and transcription factors, thereby attenuating cardiac hypertrophy. This review will
discuss the molecular mechanisms by which Trx1 exerts antihypertrophic effects in the heart.
cardiac hypertrophy. In contrast, antioxidants scavenge ROS, thereby maintaining the
reduced environment of cells and inhibiting hypertrophy in the heart. Thioredoxin1 (Trx1) not
only functions as a major antioxidant in the heart but also interacts with important signaling
molecules and transcription factors, thereby attenuating cardiac hypertrophy. This review will
discuss the molecular mechanisms by which Trx1 exerts antihypertrophic effects in the heart.
Excessive reactive oxygen species (ROS) play an important role in the development of cardiac hypertrophy. In contrast, antioxidants scavenge ROS, thereby maintaining the reduced environment of cells and inhibiting hypertrophy in the heart. Thioredoxin1 (Trx1) not only functions as a major antioxidant in the heart but also interacts with important signaling molecules and transcription factors, thereby attenuating cardiac hypertrophy. This review will discuss the molecular mechanisms by which Trx1 exerts antihypertrophic effects in the heart.
Mary Ann Liebert