Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy
MA Jeffries - Clinical Immunology, 2018 - Elsevier
Autoimmune diseases are enigmatic and complex, and most been associated with
epigenetic changes. Epigenetics describes changes in gene expression related to
environmental influences mediated by a variety of effectors that alter the three-dimensional
structure of chromatin and facilitate transcription factor or repressor binding. Recent years
have witnessed a dramatic change and acceleration in epigenetic editing approaches,
spurred on by the discovery and later development of the CRISPR/Cas9 system as a highly …
epigenetic changes. Epigenetics describes changes in gene expression related to
environmental influences mediated by a variety of effectors that alter the three-dimensional
structure of chromatin and facilitate transcription factor or repressor binding. Recent years
have witnessed a dramatic change and acceleration in epigenetic editing approaches,
spurred on by the discovery and later development of the CRISPR/Cas9 system as a highly …