Identification of a lambda toxin-negative Clostridium perfringens strain that processes and activates epsilon prototoxin intracellularly
JM Harkness, J Li, BA McClane - Anaerobe, 2012 - Elsevier
Clostridium perfringens type B and D strains produce epsilon toxin (ETX), which is one of the
most potent clostridial toxins and is involved in enteritis and enterotoxemias of domestic
animals. ETX is produced initially as an inactive prototoxin that is typically then secreted and
processed by intestinal proteases or possibly, for some strains, lambda toxin. During the
current work a unique C. perfringens strain was identified that intracellularly processes
epsilon prototoxin to an active form capable of killing MDCK cells. This activated toxin is not …
most potent clostridial toxins and is involved in enteritis and enterotoxemias of domestic
animals. ETX is produced initially as an inactive prototoxin that is typically then secreted and
processed by intestinal proteases or possibly, for some strains, lambda toxin. During the
current work a unique C. perfringens strain was identified that intracellularly processes
epsilon prototoxin to an active form capable of killing MDCK cells. This activated toxin is not …