Clostridium perfringens type D epsilon toxin (ETX) is a potent neurotoxin producing a
severe, and often fatal, neurological disorder in ruminant livestock. Microvascular damage
appears to be the fundamental action of ETX in the brain and, recently, similar vascular
injury, with subsequent severe vasogenic oedema, has been reported in the retina of rats
given ETX. Endothelial barrier antigen (EBA) is a useful marker of an intact blood–brain
barrier in rats and it has been shown that loss of EBA immunoreactivity is correlated with …