Enterobacterial adhesins and the case for studying SNPs in bacteria
SJ Weissman, SL Moseley, DE Dykhuizen… - Trends in …, 2003 - cell.com
SJ Weissman, SL Moseley, DE Dykhuizen, EV Sokurenko
Trends in microbiology, 2003•cell.comSingle-nucleotide polymorphisms (SNPs) in structural genes can have a dramatic effect on
the biology of whole organisms, from bacteria and viruses to mammals. Here, we
underscore the importance of SNPs in bacterial genes that contribute to the ability of
pathogens to cause disease. SNPs that confer an adaptive advantage for bacterial
pathogens have been discovered in the genes encoding the FimH and Dr adhesins of
Escherichia coli and, most recently, Salmonella enterica sv. Typhimurium FimH.
the biology of whole organisms, from bacteria and viruses to mammals. Here, we
underscore the importance of SNPs in bacterial genes that contribute to the ability of
pathogens to cause disease. SNPs that confer an adaptive advantage for bacterial
pathogens have been discovered in the genes encoding the FimH and Dr adhesins of
Escherichia coli and, most recently, Salmonella enterica sv. Typhimurium FimH.
Abstract
Single-nucleotide polymorphisms (SNPs) in structural genes can have a dramatic effect on the biology of whole organisms, from bacteria and viruses to mammals. Here, we underscore the importance of SNPs in bacterial genes that contribute to the ability of pathogens to cause disease. SNPs that confer an adaptive advantage for bacterial pathogens have been discovered in the genes encoding the FimH and Dr adhesins of Escherichia coli and, most recently, Salmonella enterica sv. Typhimurium FimH.
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