Mechanisms underlying the rapid degradation and elimination of the incretin hormones GLP-1 and GIP
R Mentlein - Best Practice & Research Clinical Endocrinology & …, 2009 - Elsevier
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic peptide (GIP, gastric inhibitory peptide) are secreted from intestinal L and K
cells and stimulate insulin secretion from pancreatic beta cells. However, they are
immediately inactivated mainly via N-terminal degradation by dipeptidyl peptidase IV (DPP
IV, CD26), a specialised enzyme located on the cell surface enzyme of endothelial,
epithelial and some other cell types. Cleavage by neprilysin (neutral endopeptidase) is a …
insulinotropic peptide (GIP, gastric inhibitory peptide) are secreted from intestinal L and K
cells and stimulate insulin secretion from pancreatic beta cells. However, they are
immediately inactivated mainly via N-terminal degradation by dipeptidyl peptidase IV (DPP
IV, CD26), a specialised enzyme located on the cell surface enzyme of endothelial,
epithelial and some other cell types. Cleavage by neprilysin (neutral endopeptidase) is a …