[HTML][HTML] Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG
GP Owens, A Ritchie, A Rossi, K Schaller… - Journal of Biological …, 2015 - ASBMB
Neuromyelitis optica-immunoglobulin G (NMO-IgG) binds to aquaporin-4 (AQP4) water
channels in the central nervous system leading to immune-mediated injury. We have
previously demonstrated that a high proportion of CSF plasma cells of NMO patients
produce antibody to the extracellular domains of the AQP4 protein and that recombinant IgG
(rAb) derived from these cells recapitulate pathogenic features of disease. We performed a
comprehensive mutational analysis of the three extracellular loops of the M23 isoform of …
channels in the central nervous system leading to immune-mediated injury. We have
previously demonstrated that a high proportion of CSF plasma cells of NMO patients
produce antibody to the extracellular domains of the AQP4 protein and that recombinant IgG
(rAb) derived from these cells recapitulate pathogenic features of disease. We performed a
comprehensive mutational analysis of the three extracellular loops of the M23 isoform of …