[HTML][HTML] Dual regulation of EDG1/S1P1 receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2
KR Watterson, E Johnston, C Chalmers… - Journal of Biological …, 2002 - ASBMB
Here we demonstrate that phosphorylation of the sphingosine 1-phosphate (SSP) receptor"
endothelial differentiation gene 1"(EDG1 or S1P 1) receptor is increased in response to
either SSP or phorbol 12-myristate 13-acetate (PMA) exposure but not lysophosphatidic
acid. Phosphoamino acid analysis demonstrated that SSP stimulated the accumulation of
phosphoserine and phosphothreonine but not phosphotyrosine. An inhibitor of PMA-
stimulated EDG1 phosphorylation failed to block SSP-stimulated phosphorylation …
endothelial differentiation gene 1"(EDG1 or S1P 1) receptor is increased in response to
either SSP or phorbol 12-myristate 13-acetate (PMA) exposure but not lysophosphatidic
acid. Phosphoamino acid analysis demonstrated that SSP stimulated the accumulation of
phosphoserine and phosphothreonine but not phosphotyrosine. An inhibitor of PMA-
stimulated EDG1 phosphorylation failed to block SSP-stimulated phosphorylation …