Effect of pembrolizumab after stereotactic body radiotherapy vs pembrolizumab alone on tumor response in patients with advanced non–small cell lung cancer: results …
WSME Theelen, HMU Peulen, F Lalezari… - JAMA …, 2019 - jamanetwork.com
Importance Many patients with advanced non–small cell lung cancer (NSCLC) receiving
immunotherapy show primary resistance. High-dose radiotherapy can lead to increased
tumor antigen release, improved antigen presentation, and T-cell infiltration. This
radiotherapy may enhance the effects of checkpoint inhibition. Objective To assess whether
stereotactic body radiotherapy on a single tumor site preceding pembrolizumab treatment
enhances tumor response in patients with metastatic NSCLC. Design, Setting, and …
immunotherapy show primary resistance. High-dose radiotherapy can lead to increased
tumor antigen release, improved antigen presentation, and T-cell infiltration. This
radiotherapy may enhance the effects of checkpoint inhibition. Objective To assess whether
stereotactic body radiotherapy on a single tumor site preceding pembrolizumab treatment
enhances tumor response in patients with metastatic NSCLC. Design, Setting, and …