[HTML][HTML] AB cell–dependent pathway drives chronic lung allograft rejection after ischemia–reperfusion injury in mice
Chronic lung allograft dysfunction (CLAD) limits long-term survival after lung transplant (LT).
Ischemia–reperfusion injury (IRI) promotes chronic rejection (CR) and CLAD, but the
underlying mechanisms are not well understood. To examine mechanisms linking IRI to CR,
a mouse orthotopic LT model using a minor alloantigen strain mismatch (C57BL/10 [B10, H-
2 b]→ C57BL/6 [B6, H-2 b]) and isograft controls (B6→ B6) was used with antecedent
minimal or prolonged graft storage. The latter resulted in IRI with subsequent airway and …
Ischemia–reperfusion injury (IRI) promotes chronic rejection (CR) and CLAD, but the
underlying mechanisms are not well understood. To examine mechanisms linking IRI to CR,
a mouse orthotopic LT model using a minor alloantigen strain mismatch (C57BL/10 [B10, H-
2 b]→ C57BL/6 [B6, H-2 b]) and isograft controls (B6→ B6) was used with antecedent
minimal or prolonged graft storage. The latter resulted in IRI with subsequent airway and …