A Protective Role of Donor B Cells against Ischemia-Reperfusion Injury in a Minor-Mismatched Mouse Lung Transplant Model
M Kawashima, G Teskey, B Joe, Z Guan… - The Journal of Heart …, 2021 - jhltonline.org
Purpose We showed that recipient B cells are necessary for the development of chronic
allograft fibrosis after ischemia-reperfusion injury (IRI) in a C57BL/10 (B10, H-2 b)-to-
C57BL/6 (B6, H-2 b) minor alloantigen-mismatched mouse orthotopic lung transplant model.
Whether donor-derived B cells play a specific role in this phenomenon is unknown. We
hypothesized that donor B cells play a minimal role in the recipient. Methods We performed
B10-to-B6 lung transplants with either prolonged (6h at 4° C followed by 45 min at 37° C and …
allograft fibrosis after ischemia-reperfusion injury (IRI) in a C57BL/10 (B10, H-2 b)-to-
C57BL/6 (B6, H-2 b) minor alloantigen-mismatched mouse orthotopic lung transplant model.
Whether donor-derived B cells play a specific role in this phenomenon is unknown. We
hypothesized that donor B cells play a minimal role in the recipient. Methods We performed
B10-to-B6 lung transplants with either prolonged (6h at 4° C followed by 45 min at 37° C and …