[HTML][HTML] Recent MMR vaccination in health care workers and Covid-19: A test negative case-control study
L Lundberg, M Bygdell, GS von Feilitzen, S Woxenius… - Vaccine, 2021 - Elsevier
Vaccine, 2021•Elsevier
Background It has been hypothesised that the measles-mumps-rubella (MMR) vaccine may
afford cross-protection against SARS-CoV-2 which may contribute to the wide variability in
disease severity of Covid-19. Methods We employed a test negative case-control study,
utilising a recent measles outbreak during which many healthcare workers received the
MMR vaccine, to investigate the potential protective effect of MMR against SARS-CoV-2 in
5905 subjects (n= 805 males, n= 5100 females). Results The odds ratio for testing positive …
afford cross-protection against SARS-CoV-2 which may contribute to the wide variability in
disease severity of Covid-19. Methods We employed a test negative case-control study,
utilising a recent measles outbreak during which many healthcare workers received the
MMR vaccine, to investigate the potential protective effect of MMR against SARS-CoV-2 in
5905 subjects (n= 805 males, n= 5100 females). Results The odds ratio for testing positive …
Background
It has been hypothesised that the measles-mumps-rubella (MMR) vaccine may afford cross-protection against SARS-CoV-2 which may contribute to the wide variability in disease severity of Covid-19.
Methods
We employed a test negative case-control study, utilising a recent measles outbreak during which many healthcare workers received the MMR vaccine, to investigate the potential protective effect of MMR against SARS-CoV-2 in 5905 subjects (n = 805 males, n = 5100 females).
Results
The odds ratio for testing positive for SARS-CoV-2, in recently MMR-vaccinated compared to not recently MMR-vaccinated individuals was 0.91 (95% CI 0.76, 1.09). An interaction analysis showed a significant interaction for sex. After sex-stratification, the odds ratio for testing positive for males was 0.43 (95% CI 0.24, 0.79, P = 0.006), and 1.01 (95% CI 0.83, 1.22, P = 0.92) for females.
Conclusion
Our results indicate that there may be a protective effect of the MMR vaccine against SARS-CoV-2 in males but not females.
Elsevier