[HTML][HTML] RNA viruses and the cGAS-STING pathway: reframing our understanding of innate immune sensing
LG Webb, A Fernandez-Sesma - Current opinion in virology, 2022 - Elsevier
The past decade has provided critical information about the cytoplasmic innate immune
sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes
(STING). These discoveries have broadened our understanding of the interconnectedness
of the cGAS-STING pathway with autophagy, programmed cell death, Rig-I-like receptor
(RLR) signaling, DNA independent interferon induction, and how this pathway responds to
RNA virus infection. These advances highlight how multiple families of RNA viruses are …
sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes
(STING). These discoveries have broadened our understanding of the interconnectedness
of the cGAS-STING pathway with autophagy, programmed cell death, Rig-I-like receptor
(RLR) signaling, DNA independent interferon induction, and how this pathway responds to
RNA virus infection. These advances highlight how multiple families of RNA viruses are …
